Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.45 |
| ▸ | RARG | P13631 | 8/20 | 0.45 |
| ▸ | RARA | P10276 | 7/20 | 0.45 |
| ▸ | RXRA | P19793 | 4/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8889246 | 0.92 | RXRA (0.54) | RARBRARGRARARXRARXRB | |
| SCHEMBL9210142 | 0.79 | CYP3A4 (0.54) | RARBRARGRARARXRARXRB | |
| SCHEMBL6915787 | 0.79 | RXRA (0.52) | RXRARXRBCYP3A4LMNAHPGD | |
| SCHEMBL10843379 | 0.73 | RARB (0.77) | RARBRARGRARARXRARXRB | |
| SCHEMBL10843372 | 0.73 | RARB (0.77) | RARBRARGRARARXRARXRB | |
| SCHEMBL9210037 | 0.73 | RARB (0.67) | RARBRARGRARARXRARXRB | |
| SCHEMBL8890308 | 0.72 | CCNB2 (0.40) | RXRARAB9ANPC1SMN1; SMN2PTPN1 | |
| SCHEMBL6238178 | 0.72 | RXRA (0.56) | RXRARXRBRXRGCYP3A4RAB9A | |
| SCHEMBL6917161 | 0.72 | MAOB (0.55) | RARBRARGRARARXRARXRB | |
| SCHEMBL7086116 | 0.72 | RARG (0.67) | RARBRARGRARARXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012853-A1 | DIMER-SELECTIVE RXR MODULATORS AND METHODS FOR THEIR USE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1997-04-10 | — | — | WO | disclosed |