SCHEMBL8890716

SCHEMBL8890716

CC(=O)ON=C(N)c1ccccc1NC(=O)c1ccc(F)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
CYP2D6 P10635 1/20 0.62
TSHR P16473 1/20 0.62
CYP2C19 P33261 1/20 0.62
KDM4E B2RXH2 1/20 0.57
LMNA P02545 1/20 0.57
KMT2A Q03164 4/20 0.56
MEN1 O00255 3/20 0.56
RAB9A P51151 3/20 0.53
NPC1 O15118 2/20 0.53
POLB P06746 1/20 0.53
SMN1; SMN2 Q16637 2/20 0.49
HTT P42858 1/20 0.49
PDCD1 Q15116 1/20 0.48
CD274 Q9NZQ7 1/20 0.48
CA2 P00918 1/20 0.47
HDAC1 Q13547 2/20 0.47
HDAC2 Q92769 1/20 0.47
GAA P10253 2/20 0.47
PKM P14618 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8890707 1.00 CYP1A2 (0.62) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL8901417 0.83 MEN1 (0.64) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL8901412 0.83 MEN1 (0.64) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL6001412 0.80 CYP1A2 (0.73) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL14252955 0.80 PDCD1 (0.72) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL8908002 0.79 F10 (0.48) LMNAKMT2AMEN1RAB9ANPC1
SCHEMBL8907998 0.79 F10 (0.48) LMNAKMT2AMEN1RAB9ANPC1
SCHEMBL4459274 0.77 TSHR (1.00) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL28436829 0.77 CYP1A2 (0.69) CYP1A2CYP2D6TSHRCYP2C19KDM4E
SCHEMBL29378181 0.77 TSHR (1.00) CYP1A2CYP2D6TSHRCYP2C19KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997030047-A1 FUNGICIDAL 1,2,4-OXADIAZOLES AND ANALOGUES AGREVO UK LIMITED (GB) 1997-08-21 WO disclosed