Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.68 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.68 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | GAA | P10253 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ELANE | P08246 | 1/20 | 0.64 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29378181 | 1.00 | TSHR (1.00) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL1806599 | 0.88 | CYP1A2 (0.79) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL11665959 | 0.87 | TSHR (0.77) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL9339256 | 0.86 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL4203434 | 0.86 | TSHR (0.76) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL30881829 | 0.86 | CYP2C19 (0.75) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL11045073 | 0.85 | F10 (0.77) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL22445033 | 0.85 | TSHR (0.74) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL6001412 | 0.84 | CYP1A2 (0.73) | TSHRCYP1A2CYP2D6CYP2C19KDM4E | |
| SCHEMBL13096476 | 0.84 | TSHR (0.72) | TSHRCYP1A2CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2017-02-23 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | THE GENERAL HOSPITAL CORPORATION (US) | 2014-07-03 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2009076558-A1 | METHODS TO ENHANCE EFFECTIVENESS OF BACILLUS THURINGIENSIS TOXINS | BIOLOGICAL TARGETS, INC. (US) | 2009-06-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046242-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | TSHR 4069/4885CYP1A2 3478/4885CYP2D6 3795/4885 |
| US-20140187510-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | TSHR 4069/4885CYP1A2 3478/4885CYP2D6 3795/4885 |
| US-20170049793-A1 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY | WNT1, CTNNB1, WNT3A | TSHR 4069/4885CYP1A2 3478/4885CYP2D6 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.