SCHEMBL8891901

SCHEMBL8891901

NC1(C(=O)O)C(Cc2ccc(F)c(Cl)c2)CC2C1[C@H]2C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 15/20 1.00
GRM3 Q14832 15/20 1.00
GRM8 O00222 2/20 0.42
GRM4 Q14833 1/20 0.42
GRM6 O15303 1/20 0.41
GRM7 Q14831 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8764032 1.00 GRM2 (1.00) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8764708 1.00 GRM2 (1.00) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8764439 0.90 GRM2 (0.81) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8764566 0.87 GRM2 (0.77) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8763970 0.87 GRM2 (0.77) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8891537 0.87 GRM2 (0.77) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8764501 0.86 GRM2 (0.75) GRM2GRM3GRM8GRM4GRM6
SCHEMBL8764687 0.83 GRM2 (0.71) GRM2GRM3GRM8GRM4
SCHEMBL8763907 0.82 GRM2 (0.69) GRM2GRM3GRM8GRM4
SCHEMBL8764589 0.82 GRM2 (0.69) GRM2GRM3GRM8GRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997017950-A1 SHOULDER PROSTHESIS ELI LILLY AND COMPANY (US) 1997-05-22 WO disclosed