Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.48 |
| ▸ | PDE4A | P27815 | 7/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.48 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8890302 | 0.79 | BRD4 (0.47) | NOX1BRD4 | |
| SCHEMBL8891475 | 0.79 | BRD4 (0.47) | NOX1BRD4 | |
| SCHEMBL8892009 | 0.78 | PDE4D (0.55) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15920428 | 0.72 | PDE4D (0.71) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL8888975 | 0.72 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7353637 | 0.71 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7361933 | 0.71 | PDE4D (0.76) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL7421279 | 0.71 | PDE4D (0.78) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL6874729 | 0.70 | PDE4D (0.81) | PDE4DPDE4BPDE4APDE4CCYP2B6 | |
| SCHEMBL15270505 | 0.70 | PDE4D (1.00) | PDE4DPDE4BPDE4APDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | claimed |
| WO-1997003967-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND THEIR PHARMACEUTICAL USE | RHONE-POULENC RORER LIMITED (GB) | 1997-02-06 | — | — | WO | disclosed |