Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10363747 | 0.90 | CYP26A1 (0.52) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL8699929 | 0.87 | CYP19A1 (0.53) | RAB9ANPC1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL24620883 | 0.86 | CYP19A1 (0.46) | RAB9ANPC1LMNACYP19A1CYP26A1 | |
| SCHEMBL8700396 | 0.86 | CYP19A1 (0.52) | RAB9ANPC1ALDH1A1L3MBTL1MAOB | |
| SCHEMBL8696810 | 0.86 | CYP19A1 (0.52) | RAB9ANPC1ALDH1A1KDM4EMAOB | |
| SCHEMBL10362214 | 0.85 | APP (0.43) | RAB9ANPC1ALDH1A1KDM4ECYP19A1 | |
| SCHEMBL10362213 | 0.85 | APP (0.43) | RAB9ANPC1ALDH1A1KDM4ECYP19A1 | |
| SCHEMBL10363822 | 0.82 | KMT2A (0.49) | ALDH1A1LMNAL3MBTL1KDM4EMAOB | |
| SCHEMBL8702461 | 0.82 | CYP19A1 (0.55) | MAOBCYP19A1CYP26A1CYP2A6SMN1; SMN2 | |
| SCHEMBL10362188 | 0.81 | PIM1 (0.45) | RAB9ANPC1KDM4ECYP2A6TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997023466-A1 | NOVEL COMPOUNDS WITH ANALGESIC EFFECT | ASTRA PHARMA INC. (CA) | 1997-07-03 | — | — | WO | disclosed |
| EP-0257171-B1 | (BENZOFURAN-2-YL)IMIDAZOLES HAVING PHARMACEUTICAL ACTIVITY, THEIR SALTS AND RELEVANT PRODUCTION PROCESSES | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1990-08-29 | — | — | EP | disclosed |
| US-4800208-A | (Benzofuran-2-yl)imidazoles having pharmaceutical activity, their salts and relevant production processes | A. MENARINI S.A.S. (IT) | 1989-01-24 | — | — | US | disclosed |
| EP-0257171-A1 | (Benzofuran-2-yl)imidazoles having pharmaceutical activity, their salts and relevant production processes | A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.R.L. (IT) | 1988-03-02 | — | — | EP | disclosed |
| US-4604392-A | 2-substituted benzofuran derivatives useful in treating cardiac arrhythmic, histaminic and tussive conditions | A. MENARINI S.A.S. (IT) | 1986-08-05 | — | — | US | disclosed |
| US-4485112-A | N-[(Benzofuran-2-yl)(phenyl)methyl]-alkylene diamines useful in treating arrhythmic, histaminic and tussive conditions | A. MENARINI S.A.S. (IT) | 1984-11-27 | — | — | US | disclosed |
| US-3975537-A | SUBSTITUTED BENZOFURANS | SMITH KLINE (US) | 1976-08-17 | — | — | US | disclosed |