Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.57 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.54 |
| ▸ | GAPDH | P04406 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.54 |
| ▸ | STAT6 | P42226 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3970946 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL899617 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL5033515 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL2014081 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL16555404 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL6663083 | 0.84 | LMNA (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL14931005 | 0.83 | CYP2C19 (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL343478 | 0.83 | CYP2C19 (0.62) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL2424283 | 0.83 | LMNA (0.64) | ADORA3LMNANT5EHIF1AADORA2A | |
| SCHEMBL11481461 | 0.83 | LMNA (0.61) | ADORA3LMNANT5EHIF1AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5683905-A | Vectors and cell lines capable of correctly splicing exon regions | GENENTECH, INC. (US) | 1997-11-04 | — | — | US | disclosed |
| US-5668108-A | Preparation of functional human factor VIII and pharmaceutical treatment therewith | GENENTECH, INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5654147-A | GENETIC ENGINEERING | GENENTECH, INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5633150-A | Preparation of functional human factor VIII | GENENTECH, INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5618788-A | ADMINISTERING RECOMBINANT FUNCTIONAL HUMAN FACTOR VIII TO TREAT BLOOD DISORDERS ASSOCIATED WITH DEFICIENCY | GENENTECH, INC. (US) | 1997-04-08 | — | — | US | disclosed |
| US-5618789-A | RECOMBINANTLY PRODUCED; FREE OF VIRAL CONTAMINANTS; USED IN TREATMENT OF PATIENTS DIAGNOSED WITH FACTOR VIII COAGULANT DEFICIENCY | GENENTECH, INC. (US) | 1997-04-08 | — | — | US | disclosed |
| US-4965199-A | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection | GENENTECH, INC. (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0385558-A2 | Materials and methods for genome walking | GENENTECH, INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0160457-A1 | Human factor VIII, Compositions containing it, methods and materials for use in it production | GENENTECH, INC. (US) | 1985-11-06 | — | — | EP | disclosed |