⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1061060 | 0.92 | ALDH1A1 (0.31) | — | |
| SCHEMBL6923843 | 0.90 | MEN1 (0.30) | — | |
| SCHEMBL14241092 | 0.90 | ALDH1A1 (0.34) | — | |
| SCHEMBL7443277 | 0.90 | ALDH1A1 (0.34) | — | |
| SCHEMBL829693 | 0.90 | ALDH1A1 (0.34) | — | |
| SCHEMBL11035529 | 0.90 | ALDH1A1 (0.34) | — | |
| SCHEMBL45855 | 0.82 | — | — | |
| SCHEMBL14128211 | 0.82 | — | — | |
| SCHEMBL2462839 | 0.82 | ALDH1A1 (0.32) | — | |
| SCHEMBL29992490 | 0.80 | ALDH1A1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 144 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416252-A1 | PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}- 1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B][1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE | JANSSEN PHARMACEUTICA NV (BE) | 2023-12-28 | — | — | US | claimed |
| CN-117120418-A | Process for the preparation of compound (I) | 百时美施贵宝公司 | 2023-11-24 | — | — | CN | claimed |
| EP-4225757-A1 | A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE | Bristol-Myers Squibb Company (US) | 2023-08-16 | — | — | EP | claimed |
| WO-2022081473-A1 | A PROCESS TOWARD THE MANUFACTURE OF (6R,10S)-10-{4-[5-CHLORO-2-(4-CHLORO-1H-1,2,3-TRIAZOL-1-YL)PHENYL]-6-OXO-1(6H)-PYRIMIDINYL}-1-(DIFLUOROMETHYL)-6-METHYL-1,4,7,8,9,10-HEXAHYDRO-11,15-(METHENO)PYRAZOLO[4,3-B] [1,7]DIAZACYCLOTETRADECIN-5(6H)-ONE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-04-21 | — | — | WO | claimed |
| CN-110028441-A | A kind of fluoro- 2-(1- bromine cyclopropyl of 5-) pyridine synthetic method | 江苏工程职业技术学院 | 2019-07-19 | — | — | CN | claimed |
| US-4145346-A | Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof | MERCK & CO., INC. (US) | 1979-03-20 | — | — | US | claimed |
| US-4105660-A | Preparation of 3β-hydroxy-27-norcholest-5,7-dien-25-one | MERCK & CO., INC. (US) | 1978-08-08 | — | — | US | claimed |
| US-20260132133-A1 | MACROCYCLIC HETEROCYCLES AND USES THEREOF | KUMQUAT BIOSCIENCES INC (US) | 2026-05-14 | — | — | US | disclosed |
| CN-122029163-A | Chemical for targeting chromatin remodeling complexes and uses thereof | 丹娜-法伯癌症研究院 | 2026-05-12 | — | — | CN | disclosed |
| US-12606568-B2 | SMARCA degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2026-04-21 | — | — | US | disclosed |
| EP-4688791-A1 | TRICYCLIC COMPOUNDS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2026-02-11 | — | — | EP | disclosed |
| US-12528785-B2 | MDM2 degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| EP-4676922-A1 | BIFUNCTIONAL COMPOUNDS CAPABLE OF DEGRADING ANDROGEN RECEPTORS | Astrazeneca AB (SE) | 2026-01-14 | — | — | EP | disclosed |
| WO-2008053182-A1 | IKK-β SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |
| EP-0099538-B1 | CARBACYCLINES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-09-11 | — | — | EP | disclosed |
| US-4954524-A | Carbacylcins, their preparation and use as medicinal agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-09-04 | — | — | US | disclosed |
| EP-0099538-A1 | Carbacyclines, process for their preparation and their use as medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-02-01 | — | — | EP | disclosed |
| US-4260771-A | VASODILATORS, ANTICOAGULANTS, IMMUNOLOGY | MERCK & CO., INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4145346-A | Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof | MERCK & CO., INC. (US) | 1979-03-20 | — | — | US | disclosed |
| US-4105660-A | Preparation of 3β-hydroxy-27-norcholest-5,7-dien-25-one | MERCK & CO., INC. (US) | 1978-08-08 | — | — | US | disclosed |