SCHEMBL8894883

SCHEMBL8894883

Nc1ccc(-c2ccc(N)cc2-c2ccccc2CO)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPRC P08575 2/20 0.46
NPC1 O15118 3/20 0.43
ALDH1A1 P00352 3/20 0.43
RAB9A P51151 3/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
CYP3A4 P08684 2/20 0.43
TDP1 Q9NUW8 2/20 0.43
TP53 P04637 1/20 0.43
TSHR P16473 1/20 0.43
MAPK1 P28482 1/20 0.43
PDK2 Q15119 3/20 0.42
CDK5 Q00535 1/20 0.42
CDK5R1 Q15078 1/20 0.42
LMNA P02545 2/20 0.42
HPGD P15428 2/20 0.42
MEN1 O00255 1/20 0.42
APAF1 O14727 1/20 0.42
TDP2 O95551 1/20 0.42
NSD2 O96028 1/20 0.42
PLA2G1B P04054 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3786432 0.85 DPP4 (0.48) ALDH1A1CYP3A4TDP1TP53PDK2
SCHEMBL7082336 0.85 PTPRC (0.49) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL3792060 0.81 ALDH1A1 (0.42) NPC1ALDH1A1RAB9ASMN1; SMN2CYP3A4
SCHEMBL4626943 0.81 AKR1B1 (0.41) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL7915384 0.80 PTPRC (0.40) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL29634747 0.80 PTPRC (0.59) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL28349056 0.79 ALDH1A1 (0.53) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL11507726 0.78 ALDH1A1 (0.52) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL3781311 0.78 PTGDR2 (0.50) PTPRCNPC1ALDH1A1RAB9ASMN1; SMN2
SCHEMBL3781954 0.77 CYP3A4 (0.42) ALDH1A1CYP3A4TDP1TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-9095472-A None JP disclosed
JP-H0995472-A NEW ARYLAMINE COMPOUND DERIVATIVE AND ITS PRODUCTION OJI PAPER CO LTD 1997-04-08 JP disclosed