Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.64 |
| ▸ | RXRB | P28702 | 11/20 | 0.64 |
| ▸ | RXRG | P48443 | 9/20 | 0.64 |
| ▸ | RARB | P10826 | 10/20 | 0.60 |
| ▸ | RARG | P13631 | 9/20 | 0.60 |
| ▸ | RARA | P10276 | 7/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CRABP2 | P29373 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8896551 | 0.82 | RXRA (0.47) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8052917 | 0.82 | RXRA (0.55) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL1073307 | 0.78 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| Terephthalic Acid SCHEMBL9551780 | 0.77 | RXRA (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7719786 | 0.76 | RXRA (0.72) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7716684 | 0.76 | RXRA (0.67) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7723487 | 0.75 | RXRA (1.00) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7719793 | 0.75 | RXRA (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL7952347 | 0.74 | RARB (0.70) | RXRARXRBRXRGRARBRARG | |
| SCHEMBL8522300 | 0.72 | RARB (0.58) | RXRARXRBRXRGRARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | claimed |
| US-5672710-A | SPECIFIC AGONISTS FOR THE RXR RETINOID RECEPTOR RATHER THAN THE RAR ONE; SIDE EFFECT REDUCTION; SKIN AND NERVOUS SYTEM DISORDERS; ANTICARCINOGENIC AGENTS; VISION DEFECTS | ALLERGAN (US) | 1997-09-30 | — | — | US | disclosed |
| WO-1997016422-A1 | SULFIDES, SULFOXIDES AND SULFONES DISUBSTITUTED WITH A TETRAHYDRONAPHTHALENYL, CHROMANYL, THIOCHROMANYL OR TETRAHYDROQUINOLINYL AND SUBSTITUTED PHENYL OR HETEROARYL GROUP, HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1997-05-09 | — | — | WO | disclosed |