SCHEMBL8895890

SCHEMBL8895890

O=[N+]([O-])c1nccn1C[C@H](O)CNCCBr

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.57
LMNA P02545 1/20 0.46
THRB P10828 1/20 0.46
CYP2C19 P33261 1/20 0.46
CA12 O43570 5/20 0.44
CA1 P00915 5/20 0.44
CA2 P00918 5/20 0.44
CA9 Q16790 5/20 0.44
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
OPRK1 P41145 1/20 0.40
TYMP P19971 3/20 0.39
ENO1 P06733 1/20 0.34
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PKM P14618 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NOS1 P29475 1/20 0.30
CCR10 P46092 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8895125 1.00 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL367445 1.00 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
Bromide SCHEMBL5137846 0.99 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12
Bromide SCHEMBL8855507 0.99 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855499 0.93 KMT2A (0.55) KMT2ALMNATHRBCYP2C19CA12
Bromide SCHEMBL8855612 0.92 KMT2A (0.54) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL9085514 0.89 KMT2A (0.58) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855564 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855458 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8855559 0.88 KMT2A (0.57) KMT2ALMNATHRBCYP2C19CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5659048-A CHEMOSENSITIZER, RADIOSENSITIZER ADMINISTERING TO PATIENTS WHOM ARE SENSITIVE TO RADIATION OR CHEMOTHERAPY BRITISH TECHNOLOGY GROUP LIMITED (GB) 1997-08-19 US claimed
WO-1994015922-A1 NOVEL PROCESS FOR PREPARING CHIRAL [[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-1H-IMIDAZOL-1-ETHANOL AND RELATED COMPOUNDS WARNER LAMBERT COMPANY (US) 1994-07-21 WO claimed
US-5659048-A CHEMOSENSITIZER, RADIOSENSITIZER ADMINISTERING TO PATIENTS WHOM ARE SENSITIVE TO RADIATION OR CHEMOTHERAPY BRITISH TECHNOLOGY GROUP LIMITED (GB) 1997-08-19 US disclosed
US-5543527-A ANTITUMOR AGENTS BRITISH TECHNOLOYG GROUP LIMITED (GB) 1996-08-06 US disclosed
US-5481000-A RADIOSENSITIZERS OR CHEMOSENSITIZERS; PATENT CLAIMS CHIRAL 3-/2-HYDROXY-3-/2-NITROIMIDAZOL-1-YL/PROPYL/-2-OXAZOLIDINONE, HAVING /S/ CONFIGURATION AT OH CARBON AND FREE OF /R/ CONFIGURATION WARNER-LAMBERT COMPANY (US) 1996-01-02 US disclosed
US-5342959-A Process for preparing chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and related compounds WARNER-LAMBERT COMPANY (US) 1994-08-30 US disclosed
WO-1994015922-A1 NOVEL PROCESS FOR PREPARING CHIRAL [[(2-BROMOETHYL)AMINO]METHYL]-2-NITRO-1H-IMIDAZOL-1-ETHANOL AND RELATED COMPOUNDS WARNER LAMBERT COMPANY (US) 1994-07-21 WO disclosed