Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 4/20 | 0.49 |
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892698 | 0.89 | AR (0.51) | SRD5A1ARSRD5A2KCNH2 | |
| SCHEMBL5211247 | 0.82 | AR (0.54) | SRD5A1ARSRD5A2KCNH2 | |
| SCHEMBL9116041 | 0.82 | AR (0.51) | SRD5A1ARSRD5A2KCNH2 | |
| SCHEMBL7614998 | 0.80 | AR (0.72) | ARSRD5A2KCNH2 | |
| SCHEMBL7615006 | 0.80 | AR (0.72) | ARSRD5A2KCNH2 | |
| SCHEMBL5248685 | 0.79 | AR (0.53) | SRD5A1ARSRD5A2 | |
| SCHEMBL9656004 | 0.79 | AR (0.62) | SRD5A1ARSRD5A2KCNH2 | |
| SCHEMBL9022119 | 0.78 | SRD5A2 (0.56) | SRD5A1ARSRD5A2 | |
| SCHEMBL7080627 | 0.78 | SRD5A1 (0.65) | SRD5A1ARSRD5A2 | |
| SCHEMBL5214662 | 0.78 | SRD5A1 (0.65) | SRD5A1ARSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693810-A | ENZYME INHIBITORS OF TESTOSTERONE-5ALPHA-REDUCTASE TO PREVENT OR LESSEN SYMPTOMS OF DIHYDROTESTOSTERONE-RELATED HYPERANDROGENIC CONDITIONS, E.G. PROSTATE PROBLEMS, SKIN DISORDERS | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |