Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253668 | 0.85 | ALDH1A1 (0.48) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL3807056 | 0.81 | ALDH1A1 (0.47) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL10394281 | 0.78 | ALDH1A1 (0.46) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL28745945 | 0.78 | APOBEC3G (0.36) | ALDH1A1LMNASLC6A2SLC6A4KDM4E | |
| SCHEMBL11801031 | 0.78 | KDM4E (0.47) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL592331 | 0.77 | IDO1 (0.52) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL29890976 | 0.77 | IDO1 (0.52) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL88415 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL3955458 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 | |
| SCHEMBL22701023 | 0.76 | ALDH1A1 (0.50) | ALDH1A1ADRA2CHTR1AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| EP-0391644-B1 | Aryl-substituted rhodanine derivatives | LILLY CO ELI (US) | 1996-06-19 | — | — | EP | disclosed |
| US-5356917-A | Antiischemic, antiinflammatory, antiarthritic agents, treat-ment of dystrophic mammals | ELI LILLY AND COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5158966-A | Aryl-substituted rhodanine derivatives | THE UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0500337-A1 | Composition containing aryl-substituted rhodanine derivatives for the treatment of type I diabetes | UNIVERSITY OF COLORADO FOUNDATION, INC. (US) | 1992-08-26 | — | — | EP | disclosed |