Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ESRRB | O95718 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESRRA | P11474 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7229795 | 0.91 | MAPT (0.47) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL7230875 | 0.81 | PDK2 (0.52) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL8627023 | 0.81 | ITGB3 (0.50) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL5863853 | 0.79 | PDK2 (0.50) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL8633119 | 0.78 | PDK2 (0.45) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL8627028 | 0.78 | PDK2 (0.48) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL7228535 | 0.78 | PDK2 (0.46) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL7237081 | 0.76 | SMN1; SMN2 (0.54) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL7235836 | 0.76 | PDK2 (0.53) | MAPTLMNAALDH1A1PDK2DDB1 | |
| SCHEMBL7235709 | 0.76 | PDK2 (0.46) | MAPTLMNAALDH1A1PDK2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665723-A | PIPERAZINE ISOINDOLE DERIVATIVES | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |