Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.52 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8899909 | 0.99 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2LTB4RALOX5AP | |
| SCHEMBL8899906 | 0.99 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2LTB4RALOX5AP | |
| SCHEMBL8898714 | 0.87 | CYSLTR1 (0.53) | CYSLTR1CYSLTR2ALOX5AP | |
| SCHEMBL8889593 | 0.86 | LTB4R (0.55) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8889585 | 0.86 | LTB4R (0.55) | CYSLTR1CYSLTR2LTB4R | |
| SCHEMBL8891775 | 0.83 | LTB4R (0.41) | CYSLTR1CYSLTR2LTB4RALOX5AP | |
| SCHEMBL8889592 | 0.79 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL8889705 | 0.79 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2 | |
| SCHEMBL8898717 | 0.79 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2LTB4RALOX5AP | |
| SCHEMBL8898722 | 0.79 | CYSLTR1 (0.51) | CYSLTR1CYSLTR2LTB4RALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5641789-A | INHIBITORS OF LEUKOTRIENES AND/OR BLOCKERS OF LEUKOTRIENE RECEPTORS; USEFUL IN PREVENTION OR TREATMENT OF ASTHMA, ARTHRITIS, PSORIASIS, ULCERS, MYOCARDIAL INFARCTION | PFIZER INC. (US) | 1997-06-24 | — | — | US | disclosed |