Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL9218670 | 1.00 | KDM4E (0.58) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL8898162 | 1.00 | KDM4E (0.58) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL9218663 | 1.00 | KDM4E (0.58) | KDM4EMAPTKMT2ALMNATSHR | |
| Tryptophan SCHEMBL2525328 | 0.95 | KDM4E (0.57) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL27137424 | 0.94 | KDM4E (0.58) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL29176788 | 0.94 | KDM4E (0.58) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL20164946 | 0.92 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL1533586 | 0.92 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28518234 | 0.92 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR | |
| Dl-Tryptophan SCHEMBL28512622 | 0.92 | KDM4E (0.68) | KDM4EMAPTKMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663953-A4 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN. | SCRIPPS RESEARCH INST (US) | 1997-05-02 | — | — | EP | disclosed |
| EP-0675904-A1 | HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-10-11 | — | — | EP | disclosed |
| EP-0663953-A1 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 1995-07-26 | — | — | EP | disclosed |
| WO-1994007922-A9 | HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS | — | 1994-06-23 | — | — | WO | disclosed |
| WO-1994007922-A1 | HUMAN NEUTRALIZING MONOCLONAL ANTIBODIES TO HUMAN IMMUNODEFICIENCY VIRUS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-04-14 | — | — | WO | disclosed |
| WO-1994005781-A1 | PHAGEMIDS COEXPRESSING A SURFACE RECEPTOR AND A SURFACE HETEROLOGOUS PROTEIN | THE SCRIPPS RESEARCH INSTITUTE (US) | 1994-03-17 | — | — | WO | disclosed |
| WO-1992019647-A1 | INTEGRIN ALPHA SUBUNIT CYTOPLASMIC DOMAIN POLYPEPTIDES, ANTIBODIES AND METHODS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1992-11-12 | — | — | WO | disclosed |