Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MPO | P05164 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 10/20 | 0.43 |
| ▸ | BCHE | P06276 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tryptophan SCHEMBL8898168 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL8898162 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL29176788 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL9218663 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL27137424 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Tryptophan SCHEMBL9218670 | 0.95 | KDM4E (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28130701 | 0.95 | KDM4E (0.63) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28861116 | 0.92 | KMT2A (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL28131402 | 0.92 | KMT2A (0.58) | KDM4EMAPTLMNATSHRBLM | |
| Dl-Tryptophan SCHEMBL1533586 | 0.92 | KDM4E (0.68) | KDM4EMAPTLMNATSHRBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9068231-B2 | Method for screening cancer therapeutic agent using galectin-3, GSK-3β, and fascin-1 | NATIONAL CANCER CENTER (KR) | 2015-06-30 | — | — | US | disclosed |
| US-20110250584-A1 | Method for Screening Cancer Therapeutic Agent Using Galectin-3, GSK-3Betta, and Fascin-1 | NATIONAL CANCER CENTER (KR) | 2011-10-13 | — | — | US | disclosed |