Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | HPGD | P15428 | 7/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TOP2A | P11388 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046101 | 0.92 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL134294 | 0.89 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL20769825 | 0.89 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| (S)-Temafloxacin SCHEMBL48096 | 0.89 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL29414891 | 0.89 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL48095 | 0.89 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL134293 | 0.88 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| (S)-Temafloxacin SCHEMBL9667109 | 0.88 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL9667105 | 0.88 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| Temafloxacin SCHEMBL2637551 | 0.88 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507851-B1 | QUINOLONE CARBOXYLIC ACID--METAL ION--ACID COMPLEXES | ABBOTT LAB (US) | 1997-04-02 | — | — | EP | claimed |
| EP-0422485-B1 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0422485-A2 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |