Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 5/20 | 0.79 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.76 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.74 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.72 |
| ▸ | PPARG | P37231 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.72 |
| ▸ | PTGES | O14684 | 1/20 | 0.72 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | ALB | P02768 | 1/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.72 |
| ▸ | AR | P10275 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17369615 | 0.89 | PTGS1 (0.82) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL31329288 | 0.89 | PTGS1 (0.77) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL5019994 | 0.88 | PTGS1 (1.00) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL17354682 | 0.88 | PTGS1 (0.84) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL5809970 | 0.88 | PTGS1 (0.76) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL13653012 | 0.87 | PTGS2 (0.80) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL17384883 | 0.87 | PTGS1 (0.77) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL23603154 | 0.86 | PTGS1 (0.71) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL14886616 | 0.86 | PTGS1 (1.00) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 | |
| SCHEMBL4538035 | 0.86 | PTGS1 (0.83) | PTGS1AKR1C3AKR1C2PTGS2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997041100-A1 | IMINOXY DERIVATIVES OF INDOLE AND INDENE COMPOUNDS AS INHIBITORS OF PROSTAGLANDIN BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-11-06 | — | — | WO | disclosed |