Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.32 |
| ▸ | JAK3 | P52333 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737926 | 0.88 | PLG (0.35) | SMN1; SMN2PLGPLATLMNAMCL1 | |
| SCHEMBL14737925 | 0.88 | PLG (0.35) | SMN1; SMN2PLGPLATLMNAMCL1 | |
| SCHEMBL20501699 | 0.81 | PLG (0.54) | PLGPLATLMNAKMT2AALDH1A1 | |
| SCHEMBL20501700 | 0.81 | PLG (0.54) | PLGPLATLMNAKMT2AALDH1A1 | |
| SCHEMBL24228415 | 0.79 | KMT2A (0.34) | PLGPLATLMNAKMT2AALDH1A1 | |
| SCHEMBL2162286 | 0.76 | JAK2 (0.33) | KMT2AALDH1A1HSD11B1CYP3A4JAK2 | |
| SCHEMBL365047 | 0.76 | — | — | |
| SCHEMBL24197645 | 0.76 | JAK2 (0.33) | KMT2AALDH1A1HSD11B1CYP3A4JAK2 | |
| SCHEMBL13907209 | 0.76 | JAK2 (0.33) | KMT2AALDH1A1HSD11B1CYP3A4JAK2 | |
| Bromide SCHEMBL30923588 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997020823-A2 | 2-AMINO QUINAZOLINE DERIVATIVES AS NPY RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 1997-06-12 | — | — | WO | disclosed |