Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365047 | 1.00 | — | — | |
| SCHEMBL24197645 | 1.00 | JAK2 (0.33) | JAK2JAK1TYK2JAK3KMT2A | |
| SCHEMBL13907209 | 1.00 | JAK2 (0.33) | JAK2JAK1TYK2JAK3KMT2A | |
| Bromide SCHEMBL30923588 | 0.97 | — | — | |
| SCHEMBL27350836 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL30503012 | 0.97 | — | — | |
| Acetonitrile SCHEMBL7798831 | 0.91 | — | — | |
| SCHEMBL2974620 | 0.88 | — | — | |
| SCHEMBL1437260 | 0.87 | — | — | |
| SCHEMBL938283 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169628-A1 | THERAPEUTIC AGENTS AND METHODS OF TREATMENT | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2022-06-02 | — | — | US | disclosed |
| CN-112920180-A | Glutaminase inhibitors | 理森制药股份公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-105960405-B | Glutaminase inhibitors | 理森制药股份公司 | 2021-02-19 | — | — | CN | disclosed |
| EP-3184171-B1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2019-03-20 | — | — | EP | disclosed |
| US-10144752-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2018-12-04 | — | — | US | disclosed |
| US-20170305945-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP | 2017-10-26 | — | — | US | disclosed |
| US-9732106-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2017-08-15 | — | — | US | disclosed |
| EP-3184171-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | Chevron Phillips Chemical Company LP (US) | 2017-06-28 | — | — | EP | disclosed |
| EP-2519532-B1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL CO LP (US) | 2017-03-08 | — | — | EP | disclosed |
| EP-3092235-A2 | NOVEL INHIBITORS OF GLUTAMINASE | Rhizen Pharmaceuticals S.A. (CH) | 2016-11-16 | — | — | EP | disclosed |
| US-20140221645-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-08-07 | — | — | US | disclosed |
| US-8680003-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2014-03-25 | — | — | US | disclosed |
| US-20120309965-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2012-12-06 | — | — | US | disclosed |
| EP-2519532-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | Chevron Phillips Chemical Company LP (US) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011082192-A1 | PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS | CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) | 2011-07-07 | — | — | WO | disclosed |
| US-20100304896-A1 | POLYUREA COVERS FOR GOLF BALLS BASED ON CYCLOALIPHATIC ISOCYANATES | ACUSHNET COMPANY | 2010-12-02 | — | — | US | disclosed |
| US-20080103263-A1 | Emulsifiable Polyisocyanate | ERDEM BEDRI | 2008-05-01 | — | — | US | disclosed |
| US-20080033086-A1 | Blocked Isocyanates and Their Use in Coating Compositions | UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION | 2008-02-07 | — | — | US | disclosed |
| US-4565835-A | POLYURETHANES FROM BIS(2-ISOCYANATOETHYL)CYCLOHEXANE | THE UPJOHN COMPANY (US) | 1986-01-21 | — | — | US | disclosed |
| US-4522762-A | POLYURETHANES MADE HAVE IMPROVED RESILIENCE PROPERTIES | THE UPJOHN COMPANY (US) | 1985-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10144752-B2 | Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins | NIT2, NCLN, NPM1 | JAK2 2009/4885JAK1 2677/4885TYK2 3172/4885 |
| US-20120309965-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | JAK2 2009/4885JAK1 2677/4885TYK2 3172/4885 |
| US-20140221645-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | JAK2 2009/4885JAK1 2677/4885TYK2 3172/4885 |
| US-20170305945-A1 | Phosphinyl Amidine Compounds, Metal Complexes, Catalyst Systems, and Their Use to Oligomerize or Polymerize Olefins | NIT2, NCLN, NPM1 | JAK2 2009/4885JAK1 2677/4885TYK2 3172/4885 |
| US-20220169628-A1 | THERAPEUTIC AGENTS AND METHODS OF TREATMENT | HDGF, NFATC1, HGF | JAK2 650/4885JAK1 1330/4885TYK2 4093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.