Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7889686 | 1.00 | MAPT (0.43) | MAPTMEN1KMT2ASCN2AKDM4E | |
| Bromide SCHEMBL7880298 | 0.82 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9APOLB | |
| Bromide SCHEMBL7880295 | 0.82 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9APOLB | |
| Bromide SCHEMBL8565406 | 0.81 | FADS1 (0.39) | ALDH1A1LMNAGFERPOLB | |
| Bromide SCHEMBL8900459 | 0.81 | FADS1 (0.39) | ALDH1A1LMNAGFERPOLB | |
| Bromide SCHEMBL8897811 | 0.79 | MAPT (0.49) | MAPTKMT2AALDH1A1 | |
| Bromide SCHEMBL8563694 | 0.79 | MAPT (0.49) | MAPTKMT2AALDH1A1 | |
| Bromide SCHEMBL8898039 | 0.78 | CA12 (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL8565678 | 0.78 | CA12 (0.47) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| Bromide SCHEMBL8567118 | 0.77 | SLC6A2 (0.47) | MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |