Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 3/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8875943 | 0.79 | HMGCR (0.42) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8877102 | 0.76 | HMGCR (0.42) | HMGCRTACR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8877966 | 0.74 | HMGCR (0.46) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8875893 | 0.73 | HMGCR (0.44) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8900673 | 0.72 | HMGCR (0.48) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8876026 | 0.72 | HMGCR (0.37) | HMGCRTACR3ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8875951 | 0.71 | HMGCR (0.53) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8875947 | 0.71 | HMGCR (0.46) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8900670 | 0.69 | HMGCR (0.43) | HMGCRTACR3DHODHPDE10ASCN9A | |
| SCHEMBL8877114 | 0.69 | HMGCR (0.52) | HMGCRTACR3DHODHPDE10ASCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686433-A | CHOLESTEROL BIOSYNTHESIS INHIBITION | E.R. SQUIBB & SONS, INC. (US) | 1997-11-11 | — | — | US | disclosed |