Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.46 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 4/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901501 | 1.00 | HSP90AA1 (0.46) | HSP90AA1DNMT3BPAX8MAOAALDH1A1 | |
| SCHEMBL8902037 | 0.85 | AKT1 (0.44) | HSP90AA1MAOAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1450338 | 0.81 | MAOA (0.46) | HSP90AA1DNMT3BPAX8MAOAALDH1A1 | |
| SCHEMBL8903047 | 0.76 | NQO1 (0.40) | ALDH1A1MAPTAKT1MEN1KMT2A | |
| SCHEMBL8903328 | 0.76 | NQO1 (0.40) | ALDH1A1MAPTAKT1MEN1KMT2A | |
| SCHEMBL8900155 | 0.73 | AKT1 (0.47) | MAOAALDH1A1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL8903426 | 0.72 | KDM4E (0.37) | ALDH1A1MAPTTDP1TSHRSMN1; SMN2 | |
| SCHEMBL8901690 | 0.71 | HTT (0.36) | ALDH1A1MAPTTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL8901847 | 0.68 | CHRM1 (0.41) | PAX8MAOAALDH1A1MAPTTDP1 | |
| SCHEMBL19896487 | 0.68 | AKT1 (0.70) | HSP90AA1DNMT3BPAX8MAOAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | claimed |
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | disclosed |
| EP-0659190-A1 | ANTINEOPLASTIC HETERONAPHTHOQUINONES | BIOCHEM PHARMA INC (CA) | 1995-06-28 | — | — | EP | disclosed |
| WO-1994011382-A1 | ANTINEOPLASTIC HETERONAPHTHOQUINONES | BIOCHEM PHARMA INC. (CA) | 1994-05-26 | — | — | WO | disclosed |