Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31305210 | 0.92 | PDGFRB (0.51) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL2899450 | 0.90 | POLB (0.52) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL14993998 | 0.87 | PDGFRB (0.62) | PDGFRBFGFR1PDGFRAFLT1FGFR3 | |
| SCHEMBL12108924 | 0.87 | PDGFRB (0.55) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL30837492 | 0.87 | PDGFRB (0.55) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL31430540 | 0.87 | PDGFRB (0.48) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL8900774 | 0.86 | PDGFRB (0.45) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL4854781 | 0.86 | GAA (0.59) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL17560534 | 0.86 | POLB (0.48) | CHEK1PDGFRBFGFR1PDGFRAFLT1 | |
| SCHEMBL21834530 | 0.86 | PDGFRB (0.47) | CHEK1PDGFRBFGFR1PDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686482-A | DOPAMINE RECEPTOR ANTAGONIST | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0757985-A1 | N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |