SCHEMBL8902289

SCHEMBL8902289

CCCCCCCC/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGFR P43088 10/20 0.74
ALDH1A1 P00352 4/20 0.74
LMNA P02545 4/20 0.74
PTGER3 P43115 4/20 0.74
TBXA2R P21731 3/20 0.74
PTGER1 P34995 3/20 0.74
PTGER4 P35408 1/20 0.74
PTGDR Q13258 1/20 0.74
SLCO2A1 Q92959 1/20 0.74
HPGD P15428 2/20 0.67
ABCC4 O15439 1/20 0.67
TSHR P16473 1/20 0.60
MAPK1 P28482 1/20 0.60
HIF1A Q16665 1/20 0.60
KDM4E B2RXH2 1/20 0.58
HKDC1 Q2TB90 1/20 0.58
TDP1 Q9NUW8 1/20 0.58
SAE1 Q9UBE0 1/20 0.58
UBA2 Q9UBT2 1/20 0.58
MEN1 O00255 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8902650 1.00 PTGFR (0.74) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL8902297 1.00 PTGFR (0.74) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL8902648 1.00 PTGFR (0.74) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL8903213 1.00 PTGFR (0.74) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL18924923 0.95 PTGFR (0.73) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL4299880 0.89 PTGFR (0.69) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL4299882 0.89 PTGFR (0.69) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL11977324 0.89 PTGFR (0.69) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL8903955 0.88 ALDH1A1 (0.67) PTGFRALDH1A1LMNAPTGER3TBXA2R
SCHEMBL8903957 0.88 ALDH1A1 (0.67) PTGFRALDH1A1LMNAPTGER3TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5599837-A 15-DEOXYPROSTAGLANDINS SHIONOGI & CO., LTD. (JP) 1997-02-04 US disclosed
EP-0471856-B1 15-DEOXYPROSTAGLANDIN DERIVATIVE SHIONOGI & CO (JP) 1995-03-22 EP disclosed
US-5292754-A Using 15-deoxyprostaglandin derivative SHIONOGI & CO., LTD. (JP) 1994-03-08 US disclosed
EP-0471856-A1 15-DEOXYPROSTAGLANDIN DERIVATIVE SHIONOGI & CO., LTD. (JP) 1992-02-26 EP disclosed