Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.31 |
| ▸ | CA2 | P00918 | 4/20 | 0.31 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA7 | P43166 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | KDM6B | O15054 | 1/20 | 0.31 |
| ▸ | KDM5C | P41229 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.31 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27873677 | 0.71 | ALDH1A1 (0.34) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL29065453 | 0.68 | NPSR1 (0.38) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL28348598 | 0.68 | NPSR1 (0.34) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL27750716 | 0.67 | TSHR (0.33) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL29065452 | 0.66 | NPSR1 (0.44) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL27731317 | 0.65 | TSHR (0.32) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL17822846 | 0.65 | KDM4E (0.34) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL5902597 | 0.65 | — | — | |
| SCHEMBL30112181 | 0.64 | NPSR1 (0.34) | NPSR1KDM4EALDH1A1TSHRCA1 | |
| SCHEMBL4337074 | 0.64 | NPSR1 (0.34) | NPSR1KDM4EALDH1A1TSHRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105884758-B | Tricyclic compounds and their use in medicine | 广东东阳光药业有限公司 | 2019-12-10 | — | — | CN | disclosed |
| US-5672599-A | DUAL ACTION ANGIOTENSIN CONVERTING ENZYME INHIBITORS AND NEUTRAL ENDOPEPTIDASE INHIBITORS; TREATMENT OF CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-09-30 | — | — | US | disclosed |