Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | STS | P08842 | 8/20 | 0.66 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.66 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.66 |
| ▸ | ESR1 | P03372 | 2/20 | 0.63 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.63 |
| ▸ | CA1 | P00915 | 2/20 | 0.63 |
| ▸ | CA2 | P00918 | 2/20 | 0.63 |
| ▸ | CA9 | Q16790 | 2/20 | 0.63 |
| ▸ | CA4 | P22748 | 1/20 | 0.63 |
| ▸ | CA6 | P23280 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12186933 | 1.00 | KDM4E (0.74) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL22070255 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL11143012 | 0.94 | KDM4E (0.72) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL22070254 | 0.92 | CYP3A4 (0.71) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL19393194 | 0.91 | STS (0.68) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL7992527 | 0.89 | CYP3A4 (0.72) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL10710176 | 0.89 | CYP3A4 (0.73) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL1977541 | 0.88 | CYP3A4 (0.80) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL22993929 | 0.88 | CYP3A4 (0.66) | KDM4EALDH1A1CYP3A4MAPTLMNA | |
| SCHEMBL3322364 | 0.88 | CYP3A4 (0.66) | KDM4EALDH1A1CYP3A4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610180-A | TOCOPHEROL AND CHOLESTEROL DERIVATIVES, CYTOPROTECTIVE AGENTS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1997-03-11 | — | — | US | disclosed |
| US-5336485-A | Administering cholestane phthalates, succinates or sulfates before administering tacrine | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1994-08-09 | — | — | US | disclosed |
| US-5198432-A | Cytoprotective agents | CENTER FOR INNOVATIVE TECHNOLOGY (US) | 1993-03-30 | — | — | US | disclosed |