Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9062941 | 0.85 | MTNR1A (0.60) | EGFRGAAMAPTMTNR1AHTT | |
| SCHEMBL6711082 | 0.85 | CYP1A2 (0.49) | GAAMAPTMTNR1AHSD17B10CREBBP | |
| SCHEMBL8652436 | 0.85 | MTNR1A (0.60) | EGFRGAAMAPTMTNR1AHTT | |
| Hydrochloric Acid SCHEMBL8653028 | 0.84 | MTNR1A (0.59) | EGFRGAAMAPTMTNR1AHTT | |
| Hydrochloric Acid SCHEMBL9542889 | 0.84 | GAA (0.44) | EGFRGAAMAPTMTNR1AMTNR1B | |
| SCHEMBL7416734 | 0.83 | GAA (0.51) | GAAMAPTMTNR1AMTNR1BEPHX2 | |
| SCHEMBL7937970 | 0.81 | TSHR (0.51) | EGFRMTNR1AHTTHSD17B10JAK2 | |
| SCHEMBL5765559 | 0.81 | MTNR1A (0.43) | GAAMAPTMTNR1AHSD17B10MTNR1B | |
| SCHEMBL5152873 | 0.81 | GAA (0.57) | EGFRGAAMAPTMTNR1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL9544373 | 0.80 | GAA (0.56) | EGFRGAAMAPTMTNR1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |