Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 5/20 | 0.71 |
| ▸ | TK2 | O00142 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.66 |
| ▸ | ALB | P02768 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL3437224 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL10382149 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL767986 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL13497202 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL12296879 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL2722555 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL14596596 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL12718344 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL21078835 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 | |
| Doxribtimine SCHEMBL778861 | 0.97 | TK1 (0.73) | TK1TK2LMNASMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677439-A | PREVENTION GENE EXPRESSION | SANOFI (FR) | 1997-10-14 | — | — | US | disclosed |
| EP-0541722-B1 | COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION | STERLING WINTHROP INC (US) | 1995-12-20 | — | — | EP | disclosed |
| EP-0541722-A1 | COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION. | STERLING WINTHROP INC (US) | 1993-05-19 | — | — | EP | disclosed |
| WO-1992002534-A2 | COMPOUNDS AND METHODS FOR INHIBITING GENE EXPRESSION | STERLING DRUG, INC. (US) | 1992-02-20 | — | — | WO | disclosed |