Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TOP2A | P11388 | 1/20 | 0.57 |
| ▸ | MPL | P40238 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5387954 | 0.95 | APEX1 (0.67) | APEX1ALDH1A1MAPK1NPSR1HSP90AA1 | |
| SCHEMBL7334282 | 0.95 | APEX1 (0.67) | APEX1ALDH1A1MAPK1NPSR1HSP90AA1 | |
| SCHEMBL3639896 | 0.92 | APEX1 (0.74) | APEX1ALDH1A1MAPK1NPSR1HSP90AA1 | |
| SCHEMBL8788713 | 0.89 | APEX1 (0.56) | APEX1ALDH1A1MAPK1NPSR1TOP2A | |
| SCHEMBL5396738 | 0.85 | NPSR1 (0.73) | APEX1ALDH1A1MAPK1NPSR1HSP90AA1 | |
| SCHEMBL8632170 | 0.85 | MAPT (0.64) | APEX1ALDH1A1MAPK1NPSR1KMT2A | |
| SCHEMBL18229547 | 0.85 | HDAC6 (0.68) | APEX1ALDH1A1MAPK1MAPTHDAC6 | |
| Guanidine SCHEMBL8688512 | 0.84 | APEX1 (0.55) | APEX1ALDH1A1MAPK1NPSR1TOP2A | |
| SCHEMBL7334277 | 0.84 | APEX1 (0.53) | APEX1ALDH1A1MAPK1NPSR1 | |
| SCHEMBL11376990 | 0.84 | PARP1 (0.63) | APEX1ALDH1A1MAPK1NPSR1MPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |