Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338079 | 0.95 | MAPT (0.61) | MAPTGAAPKMLMNAALDH1A1 | |
| SCHEMBL6015473 | 0.92 | MAPT (0.60) | MAPTGAAPKMLMNAALDH1A1 | |
| SCHEMBL8632161 | 0.90 | MAPT (0.55) | MAPTGAAPKMALDH1A1L3MBTL1 | |
| SCHEMBL1206622 | 0.87 | MAPT (0.56) | MAPTGAAPKMLMNAALDH1A1 | |
| SCHEMBL14347066 | 0.87 | ALDH1A1 (0.61) | MAPTGAAPKMLMNAALDH1A1 | |
| SCHEMBL8906012 | 0.85 | APEX1 (0.71) | MAPTALDH1A1APEX1MAPK1SMN1; SMN2 | |
| SCHEMBL7338067 | 0.85 | MAPT (0.53) | MAPTGAAPKML3MBTL1MAPK1 | |
| SCHEMBL18229547 | 0.85 | HDAC6 (0.68) | MAPTGAAPKMALDH1A1APEX1 | |
| SCHEMBL13931450 | 0.84 | NPSR1 (0.68) | MAPTGAAPKMLMNAALDH1A1 | |
| SCHEMBL24329791 | 0.83 | ALDH1A1 (0.60) | MAPTGAAPKMLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0400835-A1 | Substituted benzimidazoles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1990-12-05 | — | — | EP | disclosed |
| US-4880804-A | HYPOTENSIVE AGENTS, CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-11-14 | — | — | US | disclosed |