Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 5/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.50 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3643686 | 0.89 | AGTR1 (0.53) | HCAR3HDAC6AGTR1AGTR2MEN1 | |
| SCHEMBL9597035 | 0.89 | HDAC6 (0.50) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| SCHEMBL9597041 | 0.89 | HDAC6 (0.50) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| SCHEMBL16166414 | 0.85 | HDAC6 (0.52) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| SCHEMBL17315023 | 0.84 | HDAC6 (0.51) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| Hydrochloric Acid SCHEMBL20969064 | 0.83 | HDAC6 (0.50) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| SCHEMBL29703917 | 0.83 | HDAC6 (0.50) | HCAR3HDAC6HDAC1ALDH1A1PKM | |
| SCHEMBL3438310 | 0.82 | HDAC6 (0.57) | HCAR3HDAC6HDAC1PTGER4HSD17B10 | |
| SCHEMBL7069710 | 0.80 | HPGD (0.48) | HCAR3HDAC6HDAC1ALDH1A1PTGER4 | |
| SCHEMBL1726928 | 0.80 | JAK2 (0.60) | HDAC6AGTR1AGTR2HDAC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |