Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL751883 | 0.78 | CA2 (0.51) | CA2POLBKDM4EKMT2AMEN1 | |
| SCHEMBL750645 | 0.78 | CA2 (0.51) | CA2POLBKDM4EHPGDKMT2A | |
| SCHEMBL8906475 | 0.77 | CA1 (0.48) | CA2HPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL5700135 | 0.75 | CA2 (0.56) | CA2POLBKDM4EKMT2AMEN1 | |
| SCHEMBL12821019 | 0.75 | POLB (0.58) | CA2POLBKDM4EKMT2AMEN1 | |
| SCHEMBL777369 | 0.74 | CA2 (0.71) | CA2POLBKDM4EKMT2AMEN1 | |
| SCHEMBL12890231 | 0.74 | KMT2A (0.50) | CA2POLBHPGDKMT2AMEN1 | |
| SCHEMBL3249841 | 0.73 | CA2 (0.48) | CA2POLBKDM4EKMT2AMEN1 | |
| SCHEMBL11758463 | 0.73 | CA2 (0.46) | CA2POLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL2031618 | 0.72 | CA2 (0.58) | CA2POLBKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |