Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 9/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL319341 | 0.97 | NPC1L1 (0.57) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL318821 | 0.91 | NPC1L1 (0.57) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL318682 | 0.91 | NPC1L1 (0.54) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL8893726 | 0.90 | NPC1L1 (0.60) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL10248371 | 0.89 | NPC1L1 (0.59) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL17140929 | 0.88 | NPC1L1 (0.65) | NPC1L1OPRL1OPRM1OPRK1BDKRB2 | |
| SCHEMBL5102116 | 0.86 | NPC1L1 (0.62) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| Water SCHEMBL5142066 | 0.85 | NPC1L1 (0.61) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| Water SCHEMBL5142065 | 0.85 | NPC1L1 (0.61) | NPC1L1OPRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL5108734 | 0.81 | NPC1L1 (0.57) | NPC1L1OPRL1OPRM1OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |