Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1L1 | Q9UHC9 | 9/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.48 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908168 | 0.97 | NPC1L1 (0.56) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL17140929 | 0.89 | NPC1L1 (0.65) | NPC1L1OPRM1OPRK1OPRL1BDKRB2 | |
| SCHEMBL318821 | 0.88 | NPC1L1 (0.57) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL318682 | 0.88 | NPC1L1 (0.54) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL8893726 | 0.87 | NPC1L1 (0.60) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5102116 | 0.87 | NPC1L1 (0.62) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL10248371 | 0.86 | NPC1L1 (0.59) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| Water SCHEMBL5142065 | 0.86 | NPC1L1 (0.61) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| Water SCHEMBL5142066 | 0.86 | NPC1L1 (0.61) | NPC1L1OPRM1OPRK1OPRL1OPRD1 | |
| SCHEMBL5108734 | 0.82 | NPC1L1 (0.57) | NPC1L1OPRM1OPRK1OPRL1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138841-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2017-03-08 | — | — | EP | disclosed |
| US-9156840-B2 | D2 antagonists, methods of synthesis and methods of use | Altos Therapeutics, LLC (US) | 2015-10-13 | — | — | US | disclosed |
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-11-27 | — | — | US | disclosed |
| EP-2582701-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2013-04-24 | — | — | EP | disclosed |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC | 2012-01-12 | — | — | US | disclosed |
| WO-2011160084-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | Altos Therapeutics, LLC (US) | 2011-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350005-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | NPC1L1 2825/4885OPRM1 92/4885OPRK1 29/4885 |
| US-20120010228-A1 | D2 ANTAGONISTS, METHODS OF SYNTHESIS AND METHODS OF USE | DRD2, DRD3, AVPR2 | NPC1L1 2825/4885OPRM1 92/4885OPRK1 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.