Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Diethyl Phthalate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 9/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | CDC25B | P30305 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethyl Phthalate SCHEMBL27856198 | 0.91 | TSHR (0.78) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL28775845 | 0.89 | TSHR (0.95) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL19252611 | 0.89 | TSHR (0.95) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL28168029 | 0.87 | TSHR (0.91) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL29404255 | 0.87 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL5306972 | 0.87 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL22296 | 0.87 | TSHR (1.00) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL28253758 | 0.86 | TSHR (0.70) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL2206814 | 0.85 | TSHR (0.88) | TSHRALDH1A1HSD17B10CDC25BKDM4E | |
| Diethyl Phthalate SCHEMBL30925693 | 0.85 | TSHR (0.95) | TSHRALDH1A1HSD17B10CDC25BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5603926-A | CONTAINS A (METH)ACRYLIC MONOMER HAVING AN AMINO GROUP | OSAKA YUKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1997-02-18 | — | — | US | disclosed |