Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 3/20 | 0.49 |
| ▸ | FNTB | P49356 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.48 |
| ▸ | SQLE | Q14534 | 1/20 | 0.47 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908589 | 0.86 | KDM4E (0.55) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL8908580 | 0.86 | KDM4E (0.55) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL794369 | 0.84 | KDM4E (0.60) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL794370 | 0.84 | KDM4E (0.60) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL9116583 | 0.83 | KDM4E (0.51) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL8771577 | 0.81 | GGPS1 (0.56) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL8771582 | 0.81 | GGPS1 (0.56) | KDM4EATMKMT2APOLBFNTA | |
| SCHEMBL8771778 | 0.79 | GGPS1 (0.54) | KDM4EATMFNTAFNTBGGPS1 | |
| SCHEMBL8771800 | 0.79 | GGPS1 (0.50) | FNTAFNTBGGPS1 | |
| SCHEMBL9881031 | 0.77 | KMT2A (0.67) | KDM4EATMKMT2APOLBFNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5665715-A | Farnesyl:protein transferase inhibitors as anticancer agents | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5463181-A | Farnesyl: protein transferase inhibitors as anticancer agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-31 | — | — | US | disclosed |