Toluene

Toluene

SCHEMBL8908638

CC(O)C(=O)O.Cc1ccccc1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1

The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 known ✓ O15379 1/20 0.41
HDAC4 known ✓ P56524 1/20 0.41
HDAC1 known ✓ Q13547 1/20 0.41
HDAC7 known ✓ Q8WUI4 1/20 0.41
HDAC2 known ✓ Q92769 1/20 0.41
HDAC10 known ✓ Q969S8 1/20 0.41
HDAC11 known ✓ Q96DB2 1/20 0.41
HDAC8 known ✓ Q9BY41 1/20 0.41
HDAC6 known ✓ Q9UBN7 1/20 0.41
HDAC9 known ✓ Q9UKV0 1/20 0.41
HDAC5 known ✓ Q9UQL6 1/20 0.41
LMNA P02545 4/20 0.55
TP53 P04637 2/20 0.55
TSHR P16473 2/20 0.55
ALOX12 P18054 1/20 0.55
ACHE P22303 1/20 0.55
CES2 O00748 1/20 0.48
CES1 P23141 1/20 0.48
MAPK1 P28482 1/20 0.46
KEAP1 Q14145 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL25341486 0.98 LMNA (0.52) LMNATP53TSHRALOX12ACHE
Toluene SCHEMBL27819683 0.87 LMNA (0.58) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL27527983 0.87 LMNA (0.58) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL27517251 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL6867152 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL27885366 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL9203170 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Cadaverine Tartrate SCHEMBL9732307 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Cadaverine Tartrate SCHEMBL18586007 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2
Toluene SCHEMBL27310391 0.85 LMNA (0.55) LMNATSHRALOX12ACHECES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115926405-A Ultrathin high-strength biodegradable film and preparation method thereof 前沿生物材料科技(兴安盟)有限公司 2023-04-07 CN claimed
CN-115926405-A Ultrathin high-strength biodegradable film and preparation method thereof 前沿生物材料科技(兴安盟)有限公司 2023-04-07 CN disclosed
US-5603926-A CONTAINS A (METH)ACRYLIC MONOMER HAVING AN AMINO GROUP OSAKA YUKI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-02-18 US disclosed