Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 8/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.77 |
| ▸ | CYP26B1 | Q9NR63 | 4/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | RXRB | P28702 | 4/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | RARB | P10826 | 4/20 | 0.39 |
| ▸ | RARG | P13631 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908692 | 1.00 | CYP26A1 (0.77) | CYP26A1CYP3A4CYP26B1MAPK1NPC1 | |
| SCHEMBL5429594 | 0.90 | CYP26A1 (0.65) | CYP26A1CYP3A4CYP26B1TP53RXRA | |
| SCHEMBL5429598 | 0.90 | CYP26A1 (0.65) | CYP26A1CYP3A4CYP26B1TP53RXRA | |
| SCHEMBL5081220 | 0.90 | CYP26A1 (0.76) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL5081216 | 0.90 | CYP26A1 (0.76) | CYP26A1CYP3A4CYP26B1RXRARXRB | |
| SCHEMBL5423557 | 0.89 | CYP26A1 (0.64) | CYP26A1CYP3A4CYP26B1MAPK1NPC1 | |
| SCHEMBL5423554 | 0.89 | CYP26A1 (0.64) | CYP26A1CYP3A4CYP26B1MAPK1NPC1 | |
| SCHEMBL5428141 | 0.88 | CYP26A1 (0.62) | CYP26A1CYP3A4CYP26B1MAPK1TP53 | |
| SCHEMBL5428139 | 0.88 | CYP26A1 (0.62) | CYP26A1CYP3A4CYP26B1MAPK1TP53 | |
| SCHEMBL5421804 | 0.88 | CYP26A1 (0.62) | CYP26A1CYP3A4CYP26B1MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654331-A | SKIN AND RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5476860-A | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD GALDERMA) (FR) | 1995-12-19 | — | — | US | disclosed |