Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7531533 | 0.88 | MAPT (0.37) | MAPTLMNATDP1KMT2ASLC6A2 | |
| SCHEMBL7538206 | 0.88 | NPC1 (0.37) | MAPTTDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL13979971 | 0.87 | LMNA (0.43) | MAPTLMNATDP1KMT2ASLC6A2 | |
| Trifluoromethanesulfonic Acid SCHEMBL4197431 | 0.86 | LMNA (0.36) | MAPTLMNATDP1KMT2ASLC6A2 | |
| SCHEMBL12907530 | 0.83 | NPC1 (0.40) | MAPTLMNATDP1KMT2ASLC6A2 | |
| Trifluoroacetic Acid SCHEMBL4803136 | 0.82 | LMNA (0.37) | MAPTLMNATDP1KMT2ASLC6A2 | |
| SCHEMBL7532893 | 0.82 | DHODH (0.36) | MAPTTDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL4187176 | 0.82 | MCL1 (0.39) | LMNATDP1KMT2ASLC6A2SLC6A3 | |
| SCHEMBL7538239 | 0.81 | GLRA1 (0.41) | MAPTLMNATDP1KMT2ASLC6A2 | |
| SCHEMBL13979973 | 0.81 | TDP1 (0.35) | MAPTLMNATDP1KMT2ASLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5656500-A | LIPOSOMES COUPLED TO MOLECULES WITH BIOLOGICAL ACTIVITY SELECTED FROM ANTIGENS, ANTIBODIES, AND NUCLEIC ACIDS, THESE CONJUGATE ENCAPSULATE HYDROPHILIC POLYSUBSTITUTED ARYL ACRIDINIUM ESTERS | CHIRON DIAGNOSTICS CORPORATION (US) | 1997-08-12 | — | — | US | disclosed |
| US-5595875-A | DNA, RNA, IMMUNOASSAY, CHEMILUMINESCENCE | CIBA CORNING DIAGNOSTICS CORP. (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0353971-B1 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes | CIBA CORNING DIAGNOSTICS CORP (US) | 1996-02-07 | — | — | EP | disclosed |
| US-5449556-A | Chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1995-09-12 | — | — | US | disclosed |
| US-5227489-A | Hydrophilic chemiluminescent markers | CIBA CORNING DIAGNOSTICS CORP. (US) | 1993-07-13 | — | — | US | disclosed |
| EP-0263657-B1 | POLYSUBSTITUTED ARYL ACRIDINIUM ESTERS | Ciba Corning Diagnostics Corp. (US) | 1992-05-13 | — | — | EP | disclosed |
| US-5110932-A | Chemiluminescent immunoassay | CIBA CORNING DIAGNOSTICS CORP. (US) | 1992-05-05 | — | — | US | disclosed |
| US-4918192-A | LUMINESCENCE; LABELS FOR IMMUNOASSAY | CIBA CORNING DIAGNOSTICS CORP. (US) | 1990-04-17 | — | — | US | disclosed |
| EP-0353971-A2 | Acridinium esters and method for detection of an analyte using acridinium esters and liposomes | Ciba Corning Diagnostics Corp. (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4745181-A | STABLE LABELS FOR CHEMILUMINESCENT IMMUNOASSAY | CIBA CORNING DIAGNOSTICS CORP. (US) | 1988-05-17 | — | — | US | disclosed |