Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | CTSK | P43235 | 6/20 | 0.56 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | CTSS | P25774 | 6/20 | 0.53 |
| ▸ | CTSL | P07711 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CTSB | P07858 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909282 | 1.00 | ATM (0.58) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL14590979 | 0.89 | ATM (0.57) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL14704026 | 0.87 | ATM (0.61) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL6841166 | 0.87 | ATM (0.61) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL12942877 | 0.87 | ATM (0.61) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL14590985 | 0.87 | ATM (0.54) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL9633910 | 0.86 | ATM (0.57) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL8116800 | 0.86 | CTSL (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL25933039 | 0.86 | CTSL (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL7305851 | 0.86 | CTSL (0.59) | ATMCTSKCTRB1ELANECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0416373-A2 | Amino acid derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-03-13 | — | — | EP | disclosed |