Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842579 | 0.83 | TSHR (0.42) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL7846503 | 0.78 | CA1 (0.38) | TSHRCA1CA2CA9L3MBTL1 | |
| SCHEMBL12200980 | 0.76 | TSHR (0.50) | TSHRCA1KDM4EPOLBL3MBTL1 | |
| SCHEMBL3951532 | 0.75 | KDM4E (0.50) | TSHRCA1KDM4EPOLBL3MBTL1 | |
| SCHEMBL223907 | 0.74 | TSHR (0.78) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL7871593 | 0.74 | MAPK1 (0.45) | TSHRPOLBL3MBTL1TDP1 | |
| SCHEMBL21156064 | 0.73 | TSHR (0.56) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL6886009 | 0.73 | TSHR (0.56) | TSHRCA1KDM4EPOLBL3MBTL1 | |
| SCHEMBL4675777 | 0.73 | TSHR (0.61) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL9575414 | 0.72 | TSHR (0.67) | TSHRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771319-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996002542-A1 | TRICYCLIC COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-01 | — | — | WO | disclosed |