Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | PRMT5 | O14744 | 13/20 | 0.56 |
| ▸ | WDR77 | Q9BQA1 | 13/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7864713 | 0.92 | LMNA (0.66) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7854720 | 0.86 | CYP2D6 (0.61) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7854934 | 0.86 | LMNA (0.67) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7861680 | 0.82 | TSHR (0.73) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL8910069 | 0.81 | LMNA (0.53) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7865141 | 0.79 | LMNA (0.66) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL8702329 | 0.76 | LMNA (0.57) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL12618637 | 0.76 | CYP2D6 (0.74) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7854831 | 0.76 | LMNA (0.58) | LMNAALDH1A1KDM4EGAAMAPT | |
| SCHEMBL7862516 | 0.74 | MAPT (0.62) | LMNAALDH1A1KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698565-A | TREATMENT OF PSYCHOTIC DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |