Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909629 | 0.85 | CA12 (0.39) | GABRG2GABRB3GABRA5SMN1; SMN2KDM4E | |
| SCHEMBL8909809 | 0.84 | TSHR (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9434374 | 0.84 | SMAD3 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8912086 | 0.83 | CYP2C9 (0.39) | TSHRNPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL8911562 | 0.83 | POLB (0.40) | GABRG2GABRB3GABRA5MAPK1NPSR1 | |
| SCHEMBL1388815 | 0.83 | MAPT (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL1388445 | 0.75 | CA12 (0.37) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8909720 | 0.73 | DHODH (0.38) | NPSR1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL9434967 | 0.72 | MAPT (0.42) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8156114 | 0.71 | CHRM2 (0.38) | KDM4EALDH1A1HSD17B10MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |