Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909720 | 0.92 | DHODH (0.38) | DHODHMAPTKMT2ATDP1SLC6A2 | |
| SCHEMBL1388713 | 0.89 | TDP1 (0.40) | MAPTKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL8909595 | 0.83 | DHODH (0.38) | DHODHMAPTKMT2ATDP1SLC6A2 | |
| SCHEMBL8909637 | 0.82 | TDP1 (0.40) | DHODHMAPTKMT2ATDP1SLC6A2 | |
| SCHEMBL8911173 | 0.81 | TDP1 (0.39) | MAPTKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL8909809 | 0.80 | TSHR (0.37) | MAPTKMT2AL3MBTL1CYP1A2CYP2D6 | |
| SCHEMBL9434331 | 0.76 | TDP1 (0.36) | DHODHMAPTKMT2ATDP1SLC6A2 | |
| SCHEMBL8150300 | 0.76 | MAPK1 (0.33) | PPARG | |
| SCHEMBL8910217 | 0.74 | TDP1 (0.44) | MAPTKMT2ATDP1SLC6A2SLC6A3 | |
| SCHEMBL8155106 | 0.74 | MAOB (0.43) | MAPTKMT2ATDP1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |