Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27472829 | 0.94 | DPP4 (0.63) | DPP4MAOAADRA2CKMT2ATP53 | |
| SCHEMBL1868872 | 0.85 | DPP4 (0.68) | DPP4ADRA2CKMT2ATP53MAPK1 | |
| SCHEMBL12506252 | 0.85 | DPP4 (0.60) | DPP4ADRA2CKMT2AMAPK1FOLH1 | |
| SCHEMBL5099931 | 0.82 | DPP4 (0.53) | DPP4ADRA2CKMT2APDCD1CD274 | |
| SCHEMBL28031084 | 0.82 | DPP4 (0.57) | DPP4ADRA2CKMT2AFOLH1PTGER1 | |
| SCHEMBL11334269 | 0.82 | DPP4 (0.52) | DPP4KMT2AFOLH1PTGER1PTGER4 | |
| SCHEMBL8939722 | 0.82 | DPP4 (0.52) | DPP4MAOAKMT2APTGER1PTGER4 | |
| SCHEMBL11333152 | 0.80 | DPP4 (0.65) | DPP4ADRA2CKMT2AMAPK1FOLH1 | |
| SCHEMBL3680377 | 0.80 | MAOA (0.61) | MAOATAAR1HRH1 | |
| SCHEMBL1026184 | 0.80 | PPARA (0.53) | DPP4CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016109501-A1 | AMIDE COMPOUNDS AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2016-07-07 | — | — | WO | disclosed |
| US-5614614-A | ANTIBIOTICS, CHEMICAL INTERMEDIATES | ROUSSEL UCLAF (FR) | 1997-03-25 | — | — | US | disclosed |
| US-5527780-A | BACTERICIDES | ROUSSEL UCLAF (FR) | 1996-06-18 | — | — | US | disclosed |
| EP-0596802-B1 | Erythromycin derivatives, their process of preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1996-03-20 | — | — | EP | disclosed |
| EP-0596802-A1 | Erythromycin derivatives, their process of preparation and their application as medicaments | ROUSSEL UCLAF (FR) | 1994-05-11 | — | — | EP | disclosed |
| US-4055664-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC | ARMOUR PHARMACEUTICAL COMPANY (US) | 1977-10-25 | — | — | US | disclosed |
| US-4055664-A | ANTIINFLAMMATORY, ANTIPYRETIC, ANALGESIC | ARMOUR PHARMACEUTICAL COMPANY (US) | 1977-10-25 | — | — | US | disclosed |