SCHEMBL8910997

SCHEMBL8910997

CN1CCc2c(Cl)ccc(OCc3ccncc3)c2CC1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 3/20 0.59
ADRA2B P18089 3/20 0.59
ADRA2C P18825 3/20 0.59
ADRA1D P25100 2/20 0.56
ADRA1A P35348 2/20 0.56
ADRA1B P35368 2/20 0.56
HRH4 Q9H3N8 1/20 0.42
MELK Q14680 1/20 0.40
CYP2D6 P10635 1/20 0.40
SLC6A4 P31645 1/20 0.40
USP2 O75604 1/20 0.40
HPGD P15428 1/20 0.40
PLK1 P53350 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
PREP P48147 1/20 0.39
CHRNA7 P36544 2/20 0.38
ERBB2 P04626 1/20 0.38
EPHA2 P29317 1/20 0.38
KDR P35968 1/20 0.38
POLB P06746 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8911275 0.99 ADRA2A (0.57) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL9317176 0.86 ADRA2A (0.61) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL9316690 0.83 ADRA2A (0.57) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8909576 0.80 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8911050 0.80 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
Fumaric Acid SCHEMBL9317005 0.77 ADRA2A (0.55) ADRA2AADRA2BADRA2CADRA1DADRA1A
Maleic Acid SCHEMBL9316993 0.77 ADRA2A (0.55) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8909974 0.77 ADRA2A (0.56) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL9316660 0.75 ADRA2A (0.57) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8911888 0.75 ADRA2A (0.65) ADRA2AADRA2BADRA2CADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5639748-A HYPOTENSIVE AGENTS SMITHKLINE BEECHAM CORPORATION (US) 1997-06-17 US claimed
EP-0630372-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1994-12-28 EP claimed
EP-0630372-A4 HETEROALKOXY BENZAZEPINES. SMITHKLINE BEECHAM CORP (US) 1994-07-05 EP claimed
WO-1993003015-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1993-02-18 WO claimed
US-5639748-A HYPOTENSIVE AGENTS SMITHKLINE BEECHAM CORPORATION (US) 1997-06-17 US disclosed
EP-0630372-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1994-12-28 EP disclosed
EP-0630372-A4 HETEROALKOXY BENZAZEPINES. SMITHKLINE BEECHAM CORP (US) 1994-07-05 EP disclosed
WO-1993003015-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1993-02-18 WO disclosed