Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 5/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8910503 | 0.90 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| Fumaric Acid SCHEMBL8910514 | 0.90 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8910163 | 0.78 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8910159 | 0.78 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8909974 | 0.78 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8909576 | 0.78 | ADRA2A (0.56) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8910508 | 0.77 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9317176 | 0.76 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL9316660 | 0.76 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CADRA1DADRA1A | |
| SCHEMBL8911888 | 0.76 | ADRA2A (0.65) | ADRA2AADRA2BADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639748-A | HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-06-17 | — | — | US | claimed |
| EP-0630372-A1 | HETEROALKOXY BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-28 | — | — | EP | claimed |
| EP-0630372-A4 | HETEROALKOXY BENZAZEPINES. | SMITHKLINE BEECHAM CORP (US) | 1994-07-05 | — | — | EP | claimed |
| WO-1993003015-A1 | HETEROALKOXY BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-18 | — | — | WO | claimed |
| US-5639748-A | HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0630372-A1 | HETEROALKOXY BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0630372-A4 | HETEROALKOXY BENZAZEPINES. | SMITHKLINE BEECHAM CORP (US) | 1994-07-05 | — | — | EP | disclosed |
| WO-1993003015-A1 | HETEROALKOXY BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-18 | — | — | WO | disclosed |