Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 3/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | APEX1 | P27695 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | THPO | P40225 | 2/20 | 0.61 |
| ▸ | RGS12 | O14924 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.61 |
| ▸ | IAPP | P10997 | 3/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56556 | 0.91 | TRPA1 (1.00) | TRPA1KDM4EHSD17B10TDP1POLB | |
| SCHEMBL30290839 | 0.91 | TRPA1 (1.00) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Hydrochloric Acid SCHEMBL27628625 | 0.86 | TRPA1 (0.91) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Sulfuric Acid SCHEMBL22717118 | 0.85 | TRPA1 (0.79) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Sulfuric Acid SCHEMBL29440275 | 0.85 | TRPA1 (0.79) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Ethylbenzene SCHEMBL27772545 | 0.85 | TRPA1 (0.79) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Catechol SCHEMBL9474502 | 0.84 | TRPA1 (0.86) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Catechol SCHEMBL27772538 | 0.84 | TRPA1 (0.86) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Bicarbonate SCHEMBL8910836 | 0.83 | IAPP (0.66) | TRPA1KDM4EHSD17B10TDP1POLB | |
| Toluene SCHEMBL27772532 | 0.82 | TRPA1 (0.73) | TRPA1KDM4EHSD17B10TDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681669-A | ORGANIC SOLVENT CONTAINING AN AROMATIC CARBONATE AND DISSOLVED LITHIUM SALT | UBE INDUSTRIES, LTD. (JP) | 1997-10-28 | — | — | US | disclosed |